http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-4120704-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dcb88e6c103e4974b104452c51fbb4a5 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-47 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-47 |
| filingDate | 1991-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f1eae4db21a36b320a8af04125219a5e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bfaf948f4225dc66e4077716ebe8228c |
| publicationDate | 1992-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-4120704-A1 |
| titleOfInvention | METHOD FOR PRODUCING MALONIC ACID |
| abstract | Prodn. of malonic acid (I) comprises reacting a saponifiable malonic acid deriv. (II) at an elevated temp. with an aq. alkali soln., which opt. contains water-miscible organic solvent(s), treating the soln. obtd. with a strong acidic cation exchanger at below 100 deg.C and removing most or all of the water at below 100 deg.C. (II) is pref. a mono- or dialkyl malonate, cyanoacetic acid or an alkyl cyanoacetate, esp. dimethyl or diethyl malonate. A mixt. of these derivs. can be used. A sulphonated ion exchange, e.g. Lewatit S 100 or SP 112, is pref. used. (II) is saponified with NaOH and/or KOH in the molar ratio 1:2-2.1 at 90-160 deg.C. Then, the soln. obtd. is treated with the ion exchanger at below 80 deg.C, esp. 15-30 deg.C, and finally the water is removed either by evapn. at 50-70 deg.C or azeotropically at 50-70 deg.C using an alkyl-substd. aromatic solvent. In the latter case, (I) is isolated from the resulting suspension by conventional procedures. USE/ADVANTAGE - (I) is a pharmaceutical and agrochemical intermediate. The method is simple and industrially applicable, giving (I) in yields above 98%, in a purity above 99.5% and with a residual water content of below 0.5%. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106565455-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013079397-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109593032-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9825331-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106565455-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0873984-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20190075162-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0857712-A1 |
| priorityDate | 1991-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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