http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-4037109-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bbbb31e7315b8accd6544acf506c2d88 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-0812 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-096 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-096 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-08 |
| filingDate | 1990-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_acf19d4db4c9567bba74847d17295247 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5225860e1f1197272a15249554cde5bf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e06d431d4edd5959f65c913d63102b8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ecc085ad66f3d671119bae3d829fec82 |
| publicationDate | 1991-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-4037109-A1 |
| titleOfInvention | QUARTARY ((1S, 5S) -6,6-DIMETHYLBICYCLO (3.1.1) -HEPT-2-YL) -substituted N- (2-ETHOXYETHYL) -MORPHOLINUM COMPOUNDS, AND METHODS AND INTERMEDIATES FOR THE PRODUCTION THEREOF, AND THE MEDICAMENTS CONTAINING SUCH COMPOUNDS |
| abstract | Quat. morpholinium cpds. of formula (I) are new. In (I), Z is C or R1, R2, R3 are H, halo, lower alkyl or lower alkoxy.--R4, R5 are lower alkyl and X(-) is derived from a hydrogen halide acid or a lower alkyl or aromatic sulphonic acid. Also claimed is a method for preparing (I) from the corresp. morpholino cpd. and a tri-substd. benzyl cpd. of formula (ii). (I) is e.g. N-(2-bromo-4,5-dimethoxybenzyl)- N-(2-(dimethyl-(2-((1S,2S,5S)- 6,6-dimethylbicyclo (3,1,1) hept-2-yl)-ethyl)-silyl) -ethoxy)-ethyl)-morpholinium bromide (Ia). USE/ADVANTAGE - As spasmolytic gastrointestinal motility regulators. (I) are esp. useful for calming spasms that occur in the colon and cause symptoms such as nausea, cramp etc. Unit dose is 10-200 mg. In an example, in in vitro tests on isolated guinea pig ileums, the EC(50) of (IA) against acetylcholine-induced contractions was 8.0 x 10 power (-6) mol/l. |
| priorityDate | 1990-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 74.