| abstract |
A pharmaceutical compsn., contains R-alpha-liponic acid (I) or S-alpha-liponic acid (II), opt. in salt form. Alpha-liponic acid is 1,2-dithiacyclopentan-3-valeric acid. The compsn. pref. contains carriers, adjuvants and/or diluants. When the compsn. is a soln., it contains solubilisers, esp. 2-4C alcohols with 1-3 OH gps., polyethylene glycols, amides, amino acids etc. The amt. of (I) or (II) in the compsn. is 0.1-6000 (0.1-600) mg. The compsn. is prepd. by mixing (I) or (II) with carriers etc. and homogenising at 0-120 (20-80) deg.C, filling the mixt., in unit dose quantities into compartments, and pressing to form tablets etc. The carriers are starch, cyclodextrin, silica etc. and the mixt. is opt. granulated after adding an aq. soln. contg. stabiliser, or formed into an emulsion with emulsifiers or complex builders e.g. water, glycerol, wax etc. The daily dose is 3.5-200 (7-100, esp. 35-79) mg/kg. |