http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-4029244-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5c24684033fba97d1ad845ce453a57e3 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C315-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C317-36 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C315-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C317-36 |
| filingDate | 1990-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1692a7775b0ce74ec9c99d7e8b4161ac http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_796551aaa5c1a4bfebc07dff4cc9352c |
| publicationDate | 1992-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-4029244-A1 |
| titleOfInvention | PROCESS FOR THE CHEMICAL SYNTHESIS OF OLIGONUCLEOTIDES |
| abstract | Process for the prepn. of cpds. QCl. HCl comprises reacting a cpd. of formula (II) with a chlorocarbonyl donor. Q = dansylethoxycarbonyl, i.e. 2-(5-dimethylamino-1- naphthylsulphonyl)ethoxycarbonyl; 5'-O-dansylethoxycarbonyl nucleoside derivs. of formula (I) one of A1 and A2 is R1 and the other is OH, OD1 or OD2; R1 = 4-methoxytetrahydropyran-4-yloxy, tetrahydropyran-2-yloxy, t-butyldimethylsilyloxy, 2-nitrobenzyloxy, 1-(2-chloro-4- methylphenyl)-4-methoxy -44-piperidinyloxy or 1-(2-fluorophenyl)-4- methoxy-4-piperidinyloxy; D1 = P(OR8)(NR6R7); D2 = PH(O)(OM); R6 and R7 = alkyl, cycloalkyl, benzyl or phenyl, or NR6R7 is an opt. substd. ring; R8 = 2-(4-nitrophenyl)ethyl, 2-chlorophenyl, 4-chlorophenyl, Me or opt. substd. benzyl; M = a cation; B = a gp. of formula B1-B10; R2 = pivaloyl, benzoyl, 4-t-butylbenzoyl or 2-(4-nitrophenyl)-ethoxycarbonyl; R3 = H or 2-(4-nitrophenyl)ethyl; R4 = isobutyryl, 2-(4-t-butylphenyl)acetyl or 2-(4-nitrophenyl)-ethoxycarbonyl; R5 = OR3, 4-t-butylbenzamido or 2-(4-nitrophenyl)-ethoxycarbonylamino. |
| priorityDate | 1990-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 144.