http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-4028682-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6da12764b9db9c2e24beb772d66918f7 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-06 |
| filingDate | 1990-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76b6ad27b6b8e6b6680bcde29976f963 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ca3921ea1d9ec2b32f79183feea0d387 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_734e505a57ffe9fa54c08e9506760157 |
| publicationDate | 1992-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-4028682-A1 |
| titleOfInvention | NEW ACID-SUBSTITUTED THYMIDINE DERIVATIVES WITH VIROSTATIC, CYTOSTATIC AND ANTIBACTERIAL EFFECT, METHOD FOR THE PRODUCTION THEREOF AND THE MEDICINAL PRODUCTS THEREOF |
| abstract | 3'-Azido-3'-desoxy-thymidine derivs. (I) are new. R1 = H, alkyl, halogen, trifluoromethyl or halo-alkenyl; R2 = H; or R2 + R4 = -O-; R3 = H; or R2 + R3 + -O-; R4 = H and R5 = azido or R4 = azido and R5 = H; R6 = hydroxymethyl, dibromovinyl, formyl or ethynyl. Prepn. of (I) comprises: (A) oxidn. of (II) with e.g. DMSO or DCCl, followed by a Wittig reaction to give (I) (R6 is -CH=CBr2); (B) debromination of (I) where R6 = -CH=CBr2 to (I) where R6 = -CCH, e.g. using n-BuLi; and (C) for anhydro cpds. (I) where R6 = CH2OH, treatment of corresp. O-protected cpds. with azide salt in DMF/water. USE/ADVANTAGE - Cpds. (I) are useful in treating viral diseases, tumours and bacterial infections. Compared with known nucleosides, cpds. (I) avoid resistance problems, are more selective and have fewer side effects. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2007204367-A |
| priorityDate | 1990-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 54.