| abstract |
Capsaicin derivs. of formula (I) or their physiologically hydrolysable and acceptable ester or amide or pharmaceutically acceptable salts of (I) or its ester or amide is new: (where R1 = halogen, 1-4C alkyl, phenyl, benzyl, opt. substd. benzyloxy, NO2, CN, CF3, formylamino or 1-16C alkoxy; R2 = H or R1; R3 = H or 1-4C alkyl; R4, R5 = H, halogen, 1-5C alkyl (opt. substd.), opt. substd. aryl, COOH, COOR8, or CONR9R10; R8 = 1-5C alkyl; R9, R10 = H or 1-5C alkyl; R6, R7 = as for R4 or R5 or together with the C atom to which they are attached form an opt. substd. 3-7C cycloalkyl; R = O, S or NH; X = (CH2)n or (CH2)m-CH=CH-(CH2)r; n = 1, 2 or 3; m, r = 0 or 1 to 3). |