abstract |
N-heterocyclyl methyl-spiroheterocyclic cpds. of formula (I) are new: A = a gp. (i)-(iii) R1 = H, alkyl or phenyl or cyclohexyl, both opt. substd.; X = O, S or CH2; Y = H or OH; n = 0, 1, 2 or 3. R2 = CH3, OH or OCH3; R3 = OH, acyloxy or alkoxy; Aryl opt. substd. by halo or alkyl, benzyloxy, benzoyloxy, alkyl or alkenyl, all opt substd. by Oh, acyloxy, alkoxy, benzyloxy or opt. substd. aryl. Pref. R1 = H, 1-6C alkyl or phenyl or cyclohexyl (both opt. substd. by 1-3 halo or 1-4C alkyl); R3 = OH, 1-4C acyloxy or phenyl or benzyloxy (both opt. substd. by 1-3 halo or 1-4C alkyl); 1-8C alkyl or 3-4C alkenyl, both opt, substd. by OH phenyl, 1-4C acyloxy, benzoyloxy, 1-8C alkoxy or benzyloxy. |