http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-3918898-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7718cee6e06786da662bc8512617d73c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P19-40 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-40 |
| filingDate | 1989-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ac31c60902b89c01692feb02da7d61d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_58455131d9079a77efa854f39549c247 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fc4a9ea06d679fb51a5c946109dca86c |
| publicationDate | 1990-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-3918898-A1 |
| titleOfInvention | 2 ', 3'-DIDESOXYRIBOFURANOSIDE AND A METHOD FOR THE PRODUCTION THEREOF |
| abstract | 2',3'-Dideoxyribofuranosides (I) are obtd. by transfer of a 2,-dideoxyribofuranoxyl gp. from a 2',3'-dideoxyribofuranoside (II) to an acceptor base (III) in the presence of Lactobacillus leichmannii nucleoside deoxyribosyl transferase (LL-NDT). (II) is 2',3'-dideoxycytidine. (III) is an opt. substd. purine, pyrazolo(3,4-d)pyrimidine or 8-azapurine base, esp. 4-amino-pyrazolo(3,4-d)pyrimidine, 8-azaguanine, 8-azaadenine, 3-amino-8-azaadenine, a 6-X-purine (where X = H, NH(CH2)6NH2, benzamido, ethoxycarbonylmethylthio, 4-carboxybutylthio or SH), isoguanine, 2-amino-6-methylthiopurine or 6-hydroxy-2-mercaptopurine. The LL-NDT is obtd. by homogenising an L. leichmannii culture broth, centrifuging, chromatographing the supernatant on an anion exchanger, isolating the second eluted enzyme, and purifying this by affinity chromatography on N6-(6-aminohexyl) adenine-Sepharose. |
| priorityDate | 1989-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 485.