| abstract |
Novel aryloxy alkyl amine derivatives of the general formula (I), in which A is a benzole or thiophene ring; R and R1 are, mutually independently, hydrogen, alkyl, halogen CF3 or alkoxy; R2 is alkyl, cycloalkyl, alkenyl, alkinyl, alkaryl or saturated or unsaturated aliphatic or aromatic acyl, R3 and R4 are hydrogen, alkyl, alkenyl, alkinyl or cycloalkyl with up to 8 C atoms, in which R3 and R4 may be the same or different, but not hydrogen at the same time, or in which R3 and R4 together with the nitrogen atoms bonding them form a 5 to 7-part saturated ring or a saturated heterocyclic ring which may contain an oxygen or nitrogen atom as a further heteroatom in the ring, where an additional nitrogen atom may be substituted by an alkyl radical with up to 3 C atoms. These amine derivatives and their acid addition salts have interesting pharmaceutical properties and are especially suitable as anti-arrhythmics. |