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assignee http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_da54f7ebbd2d9d8a82f92aca4d1b4e48
classificationCPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D457-06
classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D457-06
filingDate 1982-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0013552a1230a8354222007a67a7f65a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b1245fe96c2c605ca7251f37561357f4
publicationDate 1983-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber DE-3216300-A1
titleOfInvention NEW ERGOTANILIDES, THEIR PRODUCTION AND USE
abstract Novel ergot derivatives and a novel process for the preparation of ergot anilides of the general formula <IMAGE> in which C9....C10 denotes a CC single or a C=C double bond, R<2> denotes hydrogen, chlorine or bromine, R<6> denotes C1-4-alkyl and X denotes H, C1-4-alkyl, C1-4-alkoxy, fluorine, chlorine, bromine, NH2, NHR' (R' = C1-4-alkyl and -acyl), NR'R" (R<'> = C1-4-alkyl and C1-4-acyl; R" = C1-4-alkyl and R' and R" together denote a 5- or 6-membered saturated or unsaturated heterocyclic ring, in which a CH2 or CH group can be substituted by N, O or S), and SR"' (R"' = C1-4-alkyl and phenyl), by reaction of appropriate lysergic acid methyl or lysergic acid ethyl esters with a dimethylaluminium anilide in an inert solvent are described. The compounds which can be prepared according to the process are in some cases useful pharmacologically active compounds which are distinguished, in particular, by an antihypotensive activity.
priorityDate 1982-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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