http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-3039223-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2e5edd48190cba3fa70dd3975efd9831 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D505-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D505-00 |
| filingDate | 1980-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2dbacd7dfe98da8e87f75fcfbd081425 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_90cb66493d69fbe8cd7077a72c23de52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_26d7cf5e3c70bfb405c48bbae5678fe1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21e81ee5bd6f41a3ba1a906c3ea7a076 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_952591497f1e8246c0190427dd15bebb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a4a7bdf6107f676c833f83e6335742f |
| publicationDate | 1982-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-3039223-A1 |
| titleOfInvention | NEW SUBSTITUTED OXADETHIACEPHAOSPORINE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
| abstract | Pyrimidinylureido-oxa-dethia-cephalosporins (I), their tautomers (Ia) and, when E is H, their salts with (in)organic acids are new (where A is phenyl, 4-hydroxyphenyl, 2- or 3- thienyl, 2- or 3-furyl, 2-amino-4-thiazolyl, 3-chloro-4- hydroxyphenyl or 3-fluoro-4-hydroxyphenyl; Y is H or OCH3; D is H, acetoxy, or -S-Het in which Het is 1-methyl-5-tetra- zolyl, 3-methyl-1,2,4-thiadiazol-5-yl, 1,3,4-thiadiazol-5-yl, 2-methyl-1,3,4-thiadiazol-5-yl or 1-methyl-5-hydroxy-6-oxo- 1,6-dihydro-1,3,4-triazinyl; R is H, CH3, cyclopropyl, OH, OCH3, -N(R1)(R2), -NH-Z-X, -NH-(CH2)n- (R5,R6,R7-phenyl), -NH-CO-R8, or -NH(CH2)m-R9; E is H or a carboxy-protecting gp. which is readily removable in vitro or in vivo; R1 and R2 are H, aliphatic 1-6C hydrocarbyl opt. contg. 1 or 2 double bonds or a triple bond, 3-7C cycloalkyl or (3-7C cycloalkyl)-(1-2C alkyl) or R1 and R2 together form a 2-6C alkylene chain; Z is opt. branched 1-4C alkylene or 3-6C cycloalkenylene; X is CH, OH, SH, aminocarbonyl, aminosulphonyl, -CON(R3)(R4), -COR3, -COOR4, -N(R3)(R4), -NH-COR3, -NH-CO-N(R3)(R4). -NH-CS-N(R3)- (R4), -NH-SO2-R3, -OR3, -OCOR3, -SR3, -SOR3 or -SO2-R3; R3 is 1-4C alkyl and R4 is H or 1-4C alkyl, or -N(R3)(R4) is a 3- to 6-membered monocyclic heterocyclic ring; n is 0 or 1; R5, R6 and R7 are H, halogen, NH2, mono- or di(1-6C alkyl)amino, OH, 1-4C alkoxy, formamido, 2-4C aliphatic acylamino, aminocarbonyl- amino, mono- or di(1-3C alkyl)aminocarbonylamino, NO2, 1-4 alkylsulphonylamino, 2-4C alkanoyl, formyl, 1-4C alkylcarbonyloxy, or alkoxycarbonyl(oxy), CONH2, 1-4C alkylaminocarbonyl, dialkyl- aminocarbonyl, (opt. (di)-alkyl)aminocarbonyloxy or alkoxycarbonyl- amino, CN, SH, 1-3C alkylthio, alkylsulphinyl or alkylsulphonyl, aminosulphonyl, 1-6C alkyl or dialkyl-aminosulphonyl, 2-hydroxy- ethylaminosulphonyl, bis(2-hydroxyethyl)aminosulphonyl or 1-3C alkyl; R8 is H, 1-4C alkyl, ethoxy, NH2 or mono- or di(1-4C alkyl)- amino; m is 0, 1 or 2; and R9 is a 5- or 6-membered opt. substd. heterocyclic gp. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2538393-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109485659-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109485659-B |
| priorityDate | 1980-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 149.