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filingDate 1980-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 1982-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber DE-3038130-A1
titleOfInvention (ALPHA) AMYLASINE ACTIVATORS AND METHOD FOR THE PRODUCTION THEREOF
abstract The alpha-amylase inactivators HOE 467-A and HOE 467-B, and their mixts. are new. The amino acid compsn. of HOE 467-A is Asp 6; Thr 8; Ser 5; Glu 7; Pro 3; Gly 7; Ala 7; Val 8; Cys 4; Ile 2; Leu 4; Tyr 6; His 2; Lys 1; Arg 3; Tp 1, and its isoelectric point is 4.38-4.68. The inactivators are prepd. by cultivating Streptomyces tendae ATCC 31210 or HAG 1266 (the second claimed as a new organism) and recovery by adsorption on resins or by reverse-phase chromatography. The inactivators are used to regulate the level of sugars in the blood, esp. for treating diabetes, pre-diabetic states or adiposity. They are resistant to enzymatic degradation; produced no toxic signs in mice when given at 1 g per kg (intraveneously) and are pref. administered at doses of 10000-300000 amylose-inhibiting units.
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