http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-3037086-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bcd600c789c13101f39db5af4f289a97 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-02 |
| filingDate | 1980-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b97279cecbb8fcfb024d2188143c108 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7eb2ce50b7fa25948caa886d32a35321 |
| publicationDate | 1982-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-3037086-A1 |
| titleOfInvention | 3- (M-CHLORANILINO-) ACRYLIC ACID ETHYL ESTER AND A METHOD FOR THE PRODUCTION THEREOF |
| abstract | 3-(m-Chloroanilino)acrylic acid ethyl ester (I) is new. (I) is an intermediate for 4-hydroxy-7-chloroquinoline, which in turn is a precursor of antimalarials of the chloroquine type. (I) is prepd. by reaction of m-chloroaniline with sodium 3-hydroxy-acrylic acid ethyl ester in a water/alcohol solvent mixt. in the presence of a mineral acid or acetic acid. Pref. alcohols for use as solvents are 1-4C alcohols, esp. MeOH or EtOH, or ether alcohols such as methyl glycol. The ratio of alcohol to water at the end of the reaction is pref. 10:1 to 1:5, esp. 5:1 to 1:2 v/v. Reaction temp. is pref. minus 25 to plus 25 deg.C.; the trans-isomer of (I) is formed preferentially when the reaction temp. is minus 25 to plus 25 deg.C., esp. minus 10 to plus 10 deg.C. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7601864-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101020647-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4910327-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0217018-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0388744-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4772711-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-3531067-A1 |
| priorityDate | 1980-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 51.