| abstract |
3-(8-Ergolinyl)-1,1-diethylurea derivs. of formula (I) and their salts are new (where R is 2-6C alkyl). (I) have higher dopaminergic activity than lisuride hydromaleate and can be used, e.g. for inhibiting lactation and treating Parkinson's disease. (I) are prepd. by reacting the corresp. N-alkylated methyl lysergate with hydrazine, reacting the hydrazide with HNO2 to form the azide, heating to form the isocyanate, reacting with diethylamine, and opt. hydrogenating the 9,10 double bond. |