http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-2903131-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cec1f0aff18c0f523c702e3f4f221b45 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6429 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-21005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-755 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-755 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-74 |
| filingDate | 1979-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e773de6ae6986fab792cfd6a25c26f7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_43cfbbf977f75989b85c91d3145fe960 |
| publicationDate | 1979-08-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-2903131-A1 |
| titleOfInvention | PROCESS FOR PRODUCING A CONCENTRATE CONTAINING ANTIHAEMOPHILIC GLOBULIN A IN ADDITION TO A PROTHROMBIN COMPLEX AND A SOLUTION OF STORAGE-STABLE SERUM PROTEINS |
| abstract | The Parent Patent described the prepn. of an antihaemophilic globulin A (factor VIII) contg. concentrate together with a prothrombin complex (Factors II, VII, IX and X) and a soln. of storage stable serum protein, using a frozen ion exchanger plasma as starting material, which had been thawed at 2-8 degrees C and in which the supernatant plasma liq. had been sepd. from the Factor VIII-contg. protein ppte. to give a Factor VIII concentrate after work up of this cryoppte. The plasma liq. was freed from Factors II, VII, IX and X by adsorption over commercial tricalcium phosphate. Any coagulation factors or other unstable proteins remaining in the plasma liq. were adsorbed over colloidal silica gel of specific surface 50x400m2/g. A storage stable serum protein remained. In this addition, the starting material is a citrate plasma, and after thawing and sepg. the cryoppte, the supernatant is treated with a polystyrene/dibenzene/quat. amine anion exchange resin and polystyrene/sulphonate cation exchange resin. Three hepatitis-safe and therapeutic prods. can be obtd. from blood plasma stabilised with citrate as well as a fourth prod., fibrinogen. The amt. of coagulation is reduced. Citrate blood from plasmapheresis and blood donors can be used, because the disadvantages associated with the addition of the stabiliser are removed by the treatment with the ion exchangers. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2267025-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0549964-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1568709-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0549964-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1568709-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2267025-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2264069-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2264069-A2 |
| priorityDate | 1978-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 100.