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http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-20
filingDate 1978-01-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04cd088323b0307cef16b16bfa89aec1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e158899ff11211d22cbd8e84b503e12d
publicationDate 1979-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber DE-2800063-A1
titleOfInvention 10-BROMVINCAMIN, ITS PRODUCTION AND USE
abstract New vincamine derivs. is 10-bromo-vincamine (I) in optically active or racemic form. (I) and its physiologically tolerable acid addn. salts have vigilance-increasing and psychostimulant activity. Prepn. is by rearrangement of a cpd. (II) (where n is 0 and X is oxygen; or n is 1, X is H and Y is an anion. When n is 0, the rearrangement is carried out in the presence of a reducing agent (pref. triphenylphosphine). The rearrangement can be affected under acidic conditions, 10-epibromovincamine formed as by-product can be converted into (I) by e.g. boiling in xylene with silver or mercury (I) acetate.
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4285949-A
priorityDate 1978-01-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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