http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-2719050-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_05ff905fdc49089f5f25746eaeb40190 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D309-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D309-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D309-16 |
| filingDate | 1977-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_713e276a5d47edd334f9175f71af0c3d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c4370f09b12f0351ec95430a9da56234 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_306997607681033dfac6fb8838362ba6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac77dde9e7e4a9ea68c88503243caeef |
| publicationDate | 1977-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-2719050-A1 |
| titleOfInvention | DIACYLOXYIC ACIDS DERIVED FROM THE ACID-S AND THE PROCESS FOR THEIR PRODUCTION |
| abstract | New derivs. of "Acid S" are cpds. of formula (I) in which Y is an acyl residue derived from formic acid or from a 3-7C alkylcarboxylic acid. (I) are diacyloxy derivs. of the antibiotic "Acid S" produced by Polyangium cellulosum var. fulvum (ATCC 25532) and can be used as agents against fungi (including Histoplasma capsulatum and Microsporum fulvum) and gram-positive fungi). They can be used for the treatment of bacterial infections and of dermatophytic and systemic fungal infections. The minimal inhibitory concsn. of (I) against fungi in tube dilution tests are of the order of 50 to 1.56 mcg/ml. The minimal inhibitory concn. against Streptococcus pyogenes is 25 - 6.25 mcg/ml. Specific cpds. (I) include that in which Y is formyl (acid S diformate). In an example, this is prepd. by treating a soln. of acid S (118mg) in dimethylformamide (DMF) (1ml) at 0 degrees under N2 with triphenylphosphine (262mg) and Br2 (160 mg) in DMF (2.5ml) and standing 3 days at 0 degrees. |
| priorityDate | 1976-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 43.