| abstract |
Prostaglandin analogues of formula (I) and their methyl esters, cyclodextrin clathrates and salts are new (where R3 is 1,1-dimethylpentyl or 2-ethylheptyl). Cpds. (I; R3=dimethylpentyl) have selective abortive and uterus-contraction stimulating activity and can be used for oestrus and fertility regulation; they also have hypotensive activity. Cpds. (I; R3=ethylheptyl) are hypotensives. A pref. cpd. is 16,16-dimethyl-trans-DELTA 2-PGE1. |