http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-2658941-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0efa077d881a96aeb1e29b21ef1bbb58 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C251-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-70 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-70 |
| filingDate | 1976-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_10411b6b3798c41983f9d7f076a2eef8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d23704d80f48ced712ea554f8902a670 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_796749cbd3679fd11b8f0372fa9804fd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d69030d5cfafb6ec66a875dd813d3525 |
| publicationDate | 1978-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-2658941-A1 |
| titleOfInvention | PROCESS FOR PRODUCING OPTICALLY ACTIVE ALPHA-METHYL-ARYL-ALANINES |
| abstract | Imidazoline-5-one derivs. of formula (I) are new: R1 is the optical active residue of a primary amine or aminoacid. R2 is H, 1-4C alkyl, benzyl or phenyl. R3 is 1-4C alkyl (opt. substd. by alkoxy, alkylthio or dialkyamino (all 1-4C alkyl), benzyloxy, benzylthio, 1-4C acyloxy, CN, 2-5C carbalkoxy, benzoyl or phenyl (the rings opt. substd. by 103 halo, NO2, 1-4C alkyl, alkoxy, or alkylthio, benzyloxy, 1-4C acyloxy or acylamino, or by one phenoxy (itself opt. substd by 1-4C alkoxy or acyloxy), CF3 or methylenedioxy), or R3 is allyl or phenyl. R4 is 1-6C alkyl opt. substd. by alkoxy, alkylthio or dialkylamino (all 1-4C alkyl), piperidino, pyrrolidino, benzyloxy, benzylthio, CN, 2-5C carbalkoxy, benzoyl or phenyl (both opt. substd. as for corresp. gps. R3), or R4 is ClCH2 or allyl. Q is pyridyl, furyl, thienyl, naphthyl, benzothienyl or bromobenzofuran. Where R3 and R4 are different, (I) are intermediates (by conventional hydrolysis) for optically active alpha-e ethyl-arylalanines, e.g. alpha-methyl-dopa (an antihypertensive) and alpha-methyltyrosine (a tranquilliser). (I) are prepd. by alkylation of corresp. cpds. (I) where R4 is H alkylation at the 4-posn. proceeds with nearly 100% asymmetric induction (the nature of R1 determines the configuration at this position) and practically no O-alkylation occurs. In an example, 1-L-alpha-phenylethyl-4-methyl-4-benzyl-2-imidazoline-5-one was prepd. from the L-alpha-phenylethylamide of alpha-isocyanopropionic acid/n-BuLi and benzyl bromide. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8404760-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6008370-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6018052-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2324810-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6002016-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5637729-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9401410-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5650519-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10106570-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9840480-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6344564-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2693192-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AP-496-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9932319-B2 |
| priorityDate | 1976-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 183.