http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-2647395-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2d3b01fb021788dbfc32162e3ac5a12c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-10 |
| filingDate | 1976-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ab8584e0075b33c1ce9df3b4568f705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b1a6888af4a3641d2107b087eecf90c2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_003f5bf7ad8912867e04333822a5cfea |
| publicationDate | 1978-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-2647395-A1 |
| titleOfInvention | PROCESS FOR THE PREPARATION OF GLYCEROPHOSPHOCHOLIN ESTERS |
| abstract | Prepn. of glycerophosphocholine esters of formula (I) or (II); (where R1 and R2 are 7-21C opt. unsatd. alkyl and/or aryl opt. substd.) from a 2- or 3-glycerophosphocholine cpd. comprises (i) adding a silylating agent pref. trimethyl chlorosilane to a suspension of natural or synthetic glycerophosphocholine in an organic solvent in the presence of an organic proton acceptor, and then (ii) reacting with an acid chloride of formula RCOCl (R = R1 or R2). (I) are used in the pharmaceutical industry; phosphahdyl cholines are one of the main components of the natural phospholipids of plant, animal and human tissue. Silylation gives an intermediate which is soluble in organic solvents. On addn. of an acylating agent and a proton acceptor, (I) can be obtd. directly and rapidly in high yields and in homogeneous phase. Previous methods using either free glycerophosphocholine or its Cd-adduct, both of which are insol. in the reaction medium have been slow as a result of the inhomogeneity. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8513446-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2015013867-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S638391-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2011523951-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014112280-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114113405-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0251229-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0178624-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4971802-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0178624-A2 |
| priorityDate | 1976-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.