| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_204ea9f0f83d1c51a916e46a41a6a14a |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-02 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P13-04 |
| filingDate |
1976-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_10f8fc01c838e6a3f6d47ab825801eae
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d691171c348fa34778e2c3282d15f607
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_48ef668817b99cbc48176a4e3f4a1945
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_92b5dbdbb2968008aeb158620c8ee760
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9fef8c9cb766bafd47f19c127ed69696 |
| publicationDate |
1977-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
DE-2628354-A1 |
| titleOfInvention |
BESTATIN AND PROCESS FOR PRODUCING IT |
| abstract |
Bestatin of formula (I) and its acidic salts are new. Bestatin is produced by cultivation of a bestatin-producing Streptomyces in a C- and N-contg. nutrient medium under aerobic conditions. Bestatin has substantially no antibacterial activity, but it shows weak inhibition of cell (including tumour cell) growth in mammals and strong inhibition of aminopeptidase B, leucine aminopeptidase and bleomycin hydrolase. On account of its inhibition of bleomycin hydrolase, bestatin strongly synergizes the antitumour effect of bleomycin. It can therefore be used in combination with bleomycin for the treatment of squamous cell carcinoma, and in the analysis of biological functions and disease processes. |
| priorityDate |
1976-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |