abstract |
Beta-Lactam derivs. of formula (I) are new. In (I) n = 1-4, Z = C(CH3)2 or -CH2.C(A)=R = H, opt. substd. alkyl, phthalide residue or a cation. A = H, alkoxy, halo or CH2Y. Y = H, acyloxy, alkoxy, opt. substd. pyridinium, opt. substd. carbamoyl (in which the substits. may complete a ring) or SR1. R1 = acyl, alkyl, or an opt. substd. 5 or 6 membered heterocycle which may be fused to a 5 or 6 membered aromatic ring. (I) are antibiotics effective against Gram positive and negative bacteria including penicillinase-producing Staphylococci. They are administered in usual oral or pref. parenteral formulations. In an example, 7-(3,3,3-trifluoropropionylamino)cephalosporanic acid was prepd. from 7-ACA and 3,3,3-trifluoropropionyl chloride. |