http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-2620179-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0ad66884a6f2a66126d492e56e09be39 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-06 |
| filingDate | 1976-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f8ecc19925dc565339e3a069a51fbc34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_411b758bd6370c5e2eaa709a09d953de http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1968708bdc89626267f454caf3396c6f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_81a62d92cef73abedbe89f8e7fa9fe79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd4d6c9cbc96b9df8f15fcf2fedf7aee |
| publicationDate | 1977-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-2620179-A1 |
| titleOfInvention | NEW ISOCHINOLINE DERIVATIVES |
| abstract | New 2-acyl-isoquinoline derivs. are cpds. of formula (I) and salts: (where R1 is H or CH3; R2 is H or lower alkyl; R3 is H or OCHof and R4 is isopropyl or tert-butyl). (I) have high adrenergic beta-receptor blocking activity coupled with low toxicity. The beta-blocking activity can be detected on cardiac, vascular and bronchial receptors. Some cpds. (I) have a particular effect on the beta-receptors of the heart and are suitable for treating functional heart disorders. In general, (I) can be used for treating functional heart disorders, such as tachycardia, tachycardic disorders of heart rhythm, extrsystoles, angina pectoris, hyperkinetic heart syndrome etc., as well as hypertension. Specific cpds. (I) include 2-acetyl-1,2,3,4-tetrahydro-6-(2-hydroxy-3-tert-butylaminopropoxy- )-isoquinoline. In an example, this is prepd. by refluxing 2-acetyl-6-(2,3-epoxypropoxy)-1,2,3,4-tetrahydroisoquinoline withtert-butylamine. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9324461-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2007518798-A |
| priorityDate | 1975-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 162.