http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-2616304-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_da54f7ebbd2d9d8a82f92aca4d1b4e48 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D309-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C405-0025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C405-0016 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D309-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C405-00 |
| filingDate | 1976-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e453021d11b44be524a00764ac639ef2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94962f463a673528ec6d856aeac18dcf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_27eeb9104885f3fe666dbe3e49ecfe5c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e61f34ac6162d7866db07883d49a6f0a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b83f9e80df8e9ba52e50d9fd0b2045a6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3166ac2742ed8d27971a1a42e170bacb |
| publicationDate | 1977-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-2616304-A1 |
| titleOfInvention | NEW PROSTANIC ACID DERIVATIVES AND METHOD FOR THEIR PRODUCTION |
| abstract | Prostane derivs. of formula (I), esp. those of formula (II) are new: (P is any substd. prostane residue; R1 = residue of a 1-15C organic carboxylic or sulphonic acid, of an inorg. acid or the gp. CUNHR6; U = O or S; R6 = opt. substd. acid, aryl, cycloalkyl or alkyl gp.; R2 and R3 = H or 1-4C alkyl; A is CH2CH2 or cis or trans CH=CH; B is CH2CH2, trans CH=CH, C C or - H CH- with the CH2 in a or beta-posn., W = CHOH, CO (both opt. functionally modified) or - (CH3)-, the OH being in alpha or beta posn. and opt. functionally modified; D = opt. branched 1-5C alkylene or C C; E = O, S or direct bond; D and E can together represent a direct bond; R4 = alkyl, cycloalkyl, opt. substd. aryl, benzodioxol-2-yl or heterocyclyl; Z = CO or opt. modified CHOH; X Y = - H CH-, CH2CH(...R5) or CH2CO when Z = CHOH or is CH2CH(...R5) or CH=CH when Z = CO; R5 = alkyl or opt. modified OH). Also new are intermediates (III) when R2 and R3 are not both H; (I) are similar to natural PG's but their action is stronger, more selective and longer lasting. They are variously useful as luteolytics; for termination of pregnancy (some 100 times as active as PGF2a); to synchronise ovulation in cows etc.; as bronchodilators, gastric acid secretion inhibitors; anti-arrhythmics; antihypertensives and diuretics. They effect uterine muscle with virtually no effect on intestinal or vascular muscles. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7906552-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8168680-B2 |
| priorityDate | 1976-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 146.