http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-2554996-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eccd894c99fea2d1c0c8735872bb2309 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-02 |
| filingDate | 1975-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b8cbe43f9876ee84ecfdc095f1a3663c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a2c7a06254e0b7f4a13830e06907fbb |
| publicationDate | 1977-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-2554996-A1 |
| titleOfInvention | PROCESS FOR THE PREPARATION OF 3-ALKYLISOCHINOLINES |
| abstract | In a new process benzylamines are reacted with glyoxal monoacetals of formula R1-CO-CH(OR2)2, (I), (where R1 and R2 are 1-4C alkyl) and the product is cyclised by treatment with polyphosphoric acid. 3-Alkyl-isoquinolines such as 3-methylisoquinoline are useful as intermediates for pharmaceuticals. Reaction of benzylamines with (I) gives the corresponding Schiff's bases in good yields, and these can then be converted into 3-alkylisoquinolines in good yield. In an example, benzylamine and methylglyoxal dimethyl acetal are refluxed in toluene (water separated) to give 2-benzylimino-propionaldehyde dimethyl acetal. Part of this is treated with polyphosphoric acid over 2 hrs. at 60-80 degrees C and stirred 2 hrs. at 80 degrees C to give 3-methylisoquinoline. |
| priorityDate | 1975-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.