| abstract |
Compressed dosage forms and tablet table mixts. contain (a) one or more pharmacological active substances (e.g. ergotamine tartrate, acetylsalicylic acid, aminophylline etc.) and (b) a carrier mixt. made up of (i) a hydrophobic ingredient melting at 34-40 degrees C which contains one or more physiologically tolerable hydrophobic substances of the type of branched primary fatty alcohols and/or monoacidic fatty acid triglycerides and/or fatty alcohol esters, opt. together with further hydrophobic physiologically tolerable substances, (ii) one or more physiologically tolerable hydrophilic polymers and (iii), opt. further physiologically tolerable adjuvants. The formulations contain a high proportion of low-melting hydrophobic carrier materials and are suitable for use as suppositories or vaginal tablets. The tablet-table mixts. are free-flowing, despite the low-melting and hydrophobic nature of the carrier material, and permit the producn. of suppositories and vaginal tablets, etc. by compression methods rather than the moulding methods used hitherto. |