| abstract |
Morpholine derivs. of formula (I): (where the N-atom N1 is a ring member of a xanthine or phthalimide ring system; R1 and R3 are H, alkyl, aryl or alkylaryl, R2 is H, alkyl, alkenyl, hydroxyalkyl, aminoalkyl, aryl, benzyl or benzoyl; and R4 is H, alkyl, hydroxyalkyl, aryl-oxymethyl, aryl, or a heterocycle linked to the morpholine ring system via a methylene bridge, e.g. 2, 6-bis-(1, 3-dimethyl-xanthin-7-ylmethyl)-4-methylmorpholine, and their pharmacologically tolerable salts, have central stimulant (analeptic) activity unaccompanied by hypotensive effects. |