http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-2424752-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_da54f7ebbd2d9d8a82f92aca4d1b4e48 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J21-003 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J41-0088 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J41-00 |
| filingDate | 1974-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_49824154d0537c8be975fba69ff8d70c |
| publicationDate | 1975-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-2424752-A1 |
| titleOfInvention | PROCESS FOR THE PRODUCTION OF STEROID SPIRO-LACTONES |
| abstract | Steroid spirolactones of partial formula (I) e.g. 3'-(3-methoxy-1 7 beta-hydroxy-1, 3, 5-(10)-oestratriene-17-yl)-propionic acid (1' 17)-lactone, are prepd. by treating corresp. gamma-hydroxy-propionic acid dimethylamides of partial formula (II), with acidic cation exchangers. The prods. are either biologically active or are intermediates for known biologically active cpds. Thus, 3'-(17 beta-hydroxy-4-androsten-3-on17a-yl)-propio-(1' 17)-lactone may be converted by 6-dehydrogenation and reaction with thioacetic acid into the known aldosterone antagonist 3'-7 alpha-acetylthio-17 beta-hydroxy-3-oxo-4-androsten-17 alpha-yl)-propio-(1' 17)-lactone. The reaction is simple to carry out at room temp., and pure products can be isolated by simply concentrating the reaction mixt. Ketal groups used to protect keto groups during previous reactions are split off during the lactonisation, thus avoiding the need for a separate deprotection step. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4285880-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2396767-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4202823-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0000368-A1 |
| priorityDate | 1974-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 38.