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publicationDate 1975-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber DE-2342058-A1
titleOfInvention PROCESS FOR THE ISOLATION OF PURE SERUM ALBUMIN FROM BIOLOGICAL LIQUIDS
abstract Biological liqs. are treated with 15-35 vol. % alcohol in the presence of 0.1-0.6% aliphatic carboxylic acid salt with non-toxic cation and anion (6-12C) at 1-30 degrees and pH 2.5. Depending on the pH non-albumin proteins are denatured. The pH is then adjusted to 4-5 to ppte. the denatured and native proteins. This splits the albumin-complexes and adsorbs the impurities on the ppte. The supernatant soln. is sepd. at pH 4-5 to give pure serum albumin (I). Tempt. throughout 1-30 degrees C. (I) is used in medicine as transfusion medium for haemorrhages, traumatic-, burn- and surgery shock, collapse and other haemodynamic disturbances, as well as a prepn. for parenteral feeding. (I) is also used in the laboratory and albumin from animal serum is used in various industries.
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