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filingDate 1973-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f6fee60c672c15b1accf9ba31cec92c
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publicationDate 1974-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber DE-2304846-A1
titleOfInvention PROCESS FOR ENRICHMENT AND PURIFICATION OF L-LYSINE OXYGENASE, AND ITS USE AS A MEDICINAL PRODUCT
abstract L-Lysine oxygenase which catalyses the decarboxylation of L-lysine to 5-amino-valeramide is enriched and purified by fractionally treating a crude extract of a Pseudomonas fluorescens fermentation fraction with protamine sulphate. Pref., a first treatment is used to ppte. impurities, then L-lysine oxygenase is pptd. in pure form from the supernatant by adding further protamine sulphate. L-Lysine oxygenase can be used as a cytostatic agent against lysine-dependent tumours without harming the host organism, even though L-lysine is an essential amino acid.
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2418239-A1
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