http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-2262500-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2ca2e4410855da087e11bf3eea8933fa |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-38 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 |
| filingDate | 1972-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87dbea8672633fb6abda2628adcdf2a9 |
| publicationDate | 1973-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-2262500-A1 |
| titleOfInvention | 3-OXYIMINOMETHYLCEPHALOSPORINE COMPOUNDS |
| abstract | Cpds. of formula (I) and their salts: where n = 0 or 1; R1 is H and R is H, 1-8C alkanoyl, 2-8C chloro- or bromoalkanoyl, azidoacetyl, cyanoacetyl, ArC(Q)2CO, Ar'XCH2CO, ArCH(B)CO, a 2-sydnone-3-(1-3C alkanoyl) group, a group of formula: 5-aminoadipoyl (opt. N-protected by 1-3C alkanoyl or chloroalkanoyl and/or opt. carboxy-protected by benzhydryl, Cl3CCH2, 4-6C alkyl or nitrobenzyl), or NRR1 is H3N+, a salt group with an acid of pKa 4, a cyclic imide group of a 3-12C hydrocarbon dicarboxylic acid, a group of formula:- Me2NCH=N- or Et2NCH=N-; Q are each H or Me; Ar is 2- or 3-thienyl, 2- or 3-furyl, 2- or 3-pyrrolyl, or phenyl opt. substd. by Cl, Br, I, F, CF3, OH, 1-3C alkyl, 1-3C alkoxy, CN or NO2 (at least one of these being in the m- or p-posn. of the phenyl ring); X is O or S; Ar' is as Ar or is 4-pyridyl when X = S; B is NH2, NH3+, an amino group protected by PhCH2OCO, 1-4C alkoxycarbonyl, cyclopentyloxycarbonyl, cyclohexyloxycarbonyl, benzhydryloxycarbonyl, Ph3C, Cl3CCH2OCO, CONHC(NH)NH2, SO3H, phthalimido or protected as the enamine of methyl acetoacetate or acetylacetone, or B is OH, 1-6C alkanoyloxy, COOH, 2-7C alkoxycarbonyl, N3, CN or CONH2; m = 0-2; Z is CH2, CH2CH2 or O-, R2 is 4-6C tert. alkyl, 5-7C tert. alkenyl or alkynyl, PhCH2, methoxybenzyl, nitrobenzyl, Cl3CCH2, 3,5-di-(t-Bu)-4-hydroxybenzyl, MeCOOCH2, pivaloyloxymethyl, ICH2CH2, Ph2CH, phenacyl, Me3Si, succinimidomethyl, phthalimidomethyl or H; Y is H, is 1-6C alkyl, 2-6C chloro- or bromoalkyl, 6-12C aryl, 4-7C cycloalkyl, (1-3C alkylene)-X-(1-3C alkyl), CH2COOR3 or CH2CH2NMe2; R3 is H or 1-6C alkyl. Cpds. (I) in which R is an acyl group are antibiotics active against a wide range of Gram positive and negative bacteria (including Serratia marcescens). The other cpds. (I) are intermediates for such antibiotics. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1221446-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4074047-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AT-402929-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9635692-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4103084-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4144393-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4144392-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4165430-A |
| priorityDate | 1972-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 254.