http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-2244257-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5e3324a35e1615e6eede6df1be26b7dd |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-10 |
| filingDate | 1972-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_30efe2cef892de8344251bea677dd202 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d841e406ef9c91ce9c5f9b3310308cc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6c38938f306d3e0813c5d4b65d4f389c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_643a63b003f7822c3811d0be4d26f7df http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a508c7c084be5695e64651112ec5872 |
| publicationDate | 1974-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-2244257-A1 |
| titleOfInvention | 2,2'-CYCLOCYTIDINE (2,2'-ANHYDRO-ARACYTIDINE) COMPOUNDS AND METHOD FOR PREPARING THEREOF |
| abstract | New derivs. of formula (I): (where R1 is H, -H2PO3, or -CO-Z in which Z is 1-4C alkyl or phenyl; R2 is H or -H2PO3; Y is H, OH, 1-4C alkyl or 1-4C alkoxy; and X is H, halogen or CH3; provided that X, Y, R1 and R2 are not all H, or that R2 is not -H2PO3 when X, Y and R1 are H, or that R1 and R2 are not both -H2PO3 when X and Y are H), are useful as antiviral, antitumour and anticancer agents and as inters. for other therapeutically active agents. (I;R1 = H or -H2PO3, R2 = H) are obtd. by heating corresp. cpds. of formula (II): (where R'1 is H or -HPO3) with a chlorophosphoric acid and a carboxylic acid ester. (I; R1 = R2 = -H2PO3; Y = H) are obtd. by heating (II; R'1 = Y = H) with a chlorophosphonic acid. Cpds. corresp. to (I) in which R1 and R2 are both -CO-Z, Y is H and X is Br are obtd. by reacting 2,2'-cyclocytidene with Br2 in the presence of an anhydride of the formula: (Z-CP)2O. (I; R1 = acetyl, R2 = H) are obtd. by reacting (I;R1 = R2 = H) with glacial acetic acid. Cpds. corresp. to (I) in which X and Y are H and R1 and R2 are both -CO-Z are obtd. by catalytic redn. of corresp. cpds. in which X is Br. |
| priorityDate | 1972-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 128.