| abstract |
Cardio-active fluoro-substd. benzylamines. Cpds. for the treatment or prophylaxis of cardiac arrhythmia are of general formula (I) where n is 2-4; A is a 5-6 atom homocyclic or heterocyclic nucleus, opt. substd.; B is a 1-8C aliphatic or heterocyclic side chain, amino-substd. and linked to the benzene nucleus by 1 or more C atoms. Prefd. cpds. are of formula (II), where X and X' are H, alkyl, alkenyl, perfluoroalkyl, Ph, substd. phenyl, amino, alkylamino, dialkylamino, alkylsulphonamido, halogen, OH, alkoxy, alkylthio, SH, perfluoroalkylthio, alkylsulphonyl, perfluoroalkylsulphonyl, sulphamoyl, alkylsulphamoyl, dialkylsulphamoyl, n is 2 or 3; R2 and R3 are H, alkyl, alkenyl, aralkyl, alkynyl and may be linked together by an atom of N, O or S to form a 5 or 6 atom heterocycle; m is 1-4; A is Ph, a cycloaliphatic ring or a 5-6 atom heterocyclic ring or a heterocyclic ring partially or completely reduced. |