| abstract |
Cpds. of formula (I) (where R1 is H, 1-12C alkyl, 3-7C cycloalkyl, aralkyl, aryl opt. substd. by >=1 alkyl, alkylamino, dialkylamino free or etherified OH or halogen gps. or a heteroaromatic gp. esp. thienyl, furyl or pyridyl; R2 is H or 1-3C alkyl, or R1 and R2 together form 3-7C cycloalkyl; R3 is H or 1-15C alkyl) have motility-inhibiting and muscle relaxant activity, and can be used as sedatives. Cpds. (I) may be prepd. by reacting a cpd. (II) (a) with COCl2 and base followed by R3NH2; (b) with R3NCO (where R3 is pref. alkyl); or (c) with R4-CONHR3 (where R4 is alkoxy aryloxy or NHR3). |