| abstract |
Title cpds. have formula (I): (where R is H, 1-6C alkyl, 3-6C monocycloalkyl, 1-6C alkoxy or is not >12C carboxylic acyloxy; R1 is H or 1-6C alkyl; R2 is H or 1-6 C alkyl, or together with R1 is methylene or together with R1 and the attached C-atom is 3-6C monocycloalkyl; R3 is -CHO, -CH2R4, -COOR5, -CON(R6)2 or -CONHOH in which R4 is OH or a hydrolysable ether or ester; R5 is H, 1-6C alkyl or an alkali metal, and each R6 is H or 1-6C alkyl; and X is CH2, CCl2 or CF2). (I) in which R1 is H and R2 is 1-3 C alkyl or R1+R2 is methylene are anti-inflammatories, analgesics and antipyretics. (I) in which R1 is H and R2 4-6C alkyl or CR1R2 is a monocycloalkyl gp. are hypocholesterolaemics and fibrinolytic agents. |