| abstract |
The new cpds. are of formula (I) in which R1 and R2 are H, NO2, halogen, or CF3; R2 may be straight or branched 1-6C alkyl, r3 is 1-3C alkyl, and n is 1-6. The cpds. have potent tranquillising activity with the advantage that they form stable aq. soln. They may be prepared by reacting metal derivs. of benzodiazepines with X(CH2)nP(O)(R3)2 where X is halogen, alkylsulphonyl or arylsulphonyl. |