http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-2040095-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_334b26d249dc7a2d0df884c87eab5255 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D243-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D243-26 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D243-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D243-26 |
| filingDate | 1970-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d6919d1b6290b22e606e935b4c67ee69 |
| publicationDate | 1972-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-2040095-A1 |
| titleOfInvention | 7-R? -1- (R? -1) -3-hydroxy-5-phenyl-1H-1,4-benzodiazepin-2 (3H) -one |
| abstract | Novel 1,4-benzodiazepines, muscle relaxants and bronchodilators. Have formula (where R1 is H, hal, lower alkyl, alkoxy, nitro, etc. and R2 = cycloalkylmethyl) and may be prepd. by treating 7-R1-1-(R2)-5-phenyl-1H-1,4-benzodiazepin-2(3H)-one with HAc and perHAc to obtain its corresponding N-oxide, treating this with acetic anhydride to obtain the corresponding 3-acetoxy deriv. which is treated with a base. They are useful muscle relaxants and bronchodilators, as demonstrated in histamine and serotonin induced lung constriction. Pref. R1=Cl, R2= -C Also claimed are the 3-acetoxy derivs. Typical doses are 5-25 mg., 3-4 times daily tranquilliser); and 1-20 mg/kg., pref. 10 mg/kg. (bronchodilators), given either orally, i.p. or rectally. |
| priorityDate | 1970-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 42.