http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-2038121-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5c24684033fba97d1ad845ce453a57e3 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-625 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-625 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-62 |
| filingDate | 1970-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_75bfb9d060fb83ab6d345d66d3af9843 |
| publicationDate | 1972-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-2038121-A1 |
| titleOfInvention | Acyl derivatives of insulin and process for their preparation |
| abstract | Cpds. are of formula (I): (where A is 1-4C alkanoyl, phenyl-alkaoyl (1-3C alkanoyl), benzoyl, alkyl-oxycarbonyl or aralkyloxycarbonyl (1-4C alkyl), amino-acyl derived from natural alpha- or beta-amino acids or their D-enantiomers). They are prepd. by reacting insulin in a mixture of N,N-dialkylcarboxylic acid amide (total 3-6C) and aqs. buffer at pH 8-9 with excess of tert. butyloxycarbonyl azide and then with an activated ester of a carboxylic acid A - OH. The reaction product is reacted with a strong acid e.g. trifluoroacetic acid. (I) have full insulin activity but with changed physical properties such as change in iso-electric point. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0027161-A1 |
| priorityDate | 1970-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 153.