| abstract |
A shelf-stablenpharmaceutical preparation,nthe oxycodone and naloxone in a substantially non-swellable,nComprising ethylcellulose matrix, characterizednthat the active ingredients from the preparationndelayednconsistent and independent of each othernbe released, and that oxycodone based on the unit amountnof naloxone in excess,nwherein oxycodone and naloxone in the weight ratio range of not more than 25n: 1, preferably at most 20: 1, 15: 1, more preferably fromn5: 1, 4: 1, 3: 1, 2: 1 or 1: 1 are included. |