| abstract |
Cpds. (I), useful as analgesics and anti-inflammatory agents : (where R1 is Cl or NO2; R2 is isopropyl, tert.-butyl or cyclohexyl; R3 and R4 are H or one is H, the other OH, or O; R5 is OH, O-metal or O-alkyl or one of Y and Z is alkyl or tert.-aminoalkyl, esp. morpholinoalkyl, and the other is H or alkyl or NYZ is a 5-7 membered heterocyclic ring opt. contg. a further heteroatom esp. morpholino or 4-methylpiperazinyl) are prepd. by either chlorinating a 4-(4-R2-phenyl)-4-ketobutyric acid (II) after complex formation with AlCl3 and opt. reducing the keto group or nitrating a cpd. (III). |