| abstract |
A composition comprising at least one C1-esterase inhibitor, said at least one C1-esterase inhibitor being present in 400 U / ml to 500 U / ml for use in the treatment, inhibition or prevention of hereditary angioedema (HAE), and wherein (i) the composition for subcutaneous administration, (ii) the hereditary angioedema is HAE type I or type II (iii) the composition comprises at least one amino acid or a salt thereof, (iv) has a pH between 6.5 and 8.0, and (v) comprises a buffer comprising 10-30 mM sodium citrate. |