| abstract |
oralnDose form with extendednA release comprising an opioid and a dosage structurenextendednRelease, whereby the dosage structure with extendednRelease the opioid from the prolonged-dose dosage formnRelease in the presence of aqueous alcohol comprising alcoholnat a concentration equal to or greater than about 20% volume / volumenreleases, with a rationa median single dose maximum opioid plasma concentration, thenis obtained when the opioid dosage form with extendednRelease to a patient co-administered with the aqueous alcohol,nto a median single dose maximum opioid plasma concentration,nwhich is obtained when the prolonged release opioid dosage formnadministered to a patient without coadministration of the aqueous alcoholnis equal to or less than about 1.8: 1. |