abstract |
The present invention relates to a method for sequence-specific recombination of DNA in eukaryotic cells, comprising inserting into a cell of a first DNA sequence, inserting into a cell of a second DNA sequence, and performing the sequence-specific recombination by action an integrase. A most preferred embodiment relates to a method, further comprising performing a second sequence-specific recombination of DNA by the action of an integrase and a Xis factor. The present invention further relates to vectors and their use as medicaments. |