| abstract |
The invention relates to compounds of the general formula I DOLLAR A AcPhe-Aib-Aib-Aib-x-Gly-Leu-y-Aib-Hyp-Gln-z-Hyp-Aib-Pro-R (I) DOLLAR A in the R Phe -ol or Phe-al and x, y and z have the following meanings: DOLLAR A a) x is Aib and y and z is Iva; DOLLAR A b) x, y and z equal to Iva; DOLLAR A c) x and z equal Aib and y equal Iva; DOLLAR A d) x, y and z equal Aib; or DOLLAR A e) x and y equal Aib and z equal Iva; DOLLAR A or the general formula II DOLLAR A AcPhe-Iva-Gln-Aib-Ile-Thr-Aib-Leu-Aib-x-Gln-Aib-Hyp-Aib-Pro-Phe-Ser (II) DOLLAR A in the x Hyp or Pro means that are synthesized by Acremonium tubakii FH 1685 DSM 12774 during fermentation and released into the culture medium, a process for the production of the cephaibols by fermentation of Acremonium tubakii, FH 1685 DSM 12774 Isolation of the cephaibols from the culture medium and their purification, and the use of the cephaibols as pharmacologically active ingredients, in particular for combating parasites. |