| abstract |
The present invention describes the new ent-steriods of the general formula I DOLLAR F1 DOLLAR A in which R · 1 ·, R · 2 ·, R · 3 ·, R · 4 ·, R · 5 ·, R · 6 ·, R · 7 ·, R · 8 ·, R · 9 ·, R · 10 · and R · 11 · have the meanings given in the description, as active pharmaceutical ingredients which have a higher affinity in vitro for estrogen receptor preparations in rat prostate than for estrogen receptor preparations in rat uterus and have in vivo a preferential effect on the bone compared to the uterus, their production, their therapeutic use and pharmaceutical dosage forms which contain the new compounds. DOLLAR A The invention further describes the use of steroids, which are based on the (8alpha-H, 9beta-H, 10alpha-H, 13alpha-H, 14beta-H) gonan scaffold, for the treatment of diseases and conditions caused by estrogen deficiency. |