| abstract |
The present invention relates to a nucleic acid comprising a nucleotide sequence which, by binding to a transcription product of the gene coding for the alpha4 chain of the adhesion molecule VLA-4, completely or at least partially inhibits the expression of the adhesion molecule VLA-4 in mammalian cells, a vector which Contains nucleic acid, and a pharmaceutical composition which contains the nucleic acid or the vector and can be used, for example, for the mobilization of blood stem cells in mammals, for the treatment of malignant haematological diseases and for the treatment of pathological inflammatory reactions in mammals. |