| abstract |
The invention relates to compounds of formula I with inhibitory effects on farnesyltransferase. Some compounds show an in vitro inhibition of farnesyltransferase at concentrations <1 muM. DOLLAR A The compounds according to the invention have the general formula (I) DOLLAR F1 in which DOLLAR A n = 0-3; R · 1 ·, R · 2 · = H, alkyl, aryl, heteroaryl, acyl; R · 3 · = H, halogen, alkyl, aryl, heteroaryl, arylalkyl, acyl, CN, NO¶2¶, R · 4 · -X-; R · 4 · = H, alkyl, aryl, heteroaryl, aralkyl, acyl; X = NH, O, S, SO¶2¶, NHSO¶2¶, OSO¶2¶ and A, B, C = organic residues. |