| abstract |
The present invention relates to new 2,5-substituted benzenesulfonylureas and thioureas of the formula (I), DOLLAR F1 in the R (1), R (2), R (3), R (4), X and Y in the Claims have meanings which have an inhibitory effect on ATP-sensitive potassium channels and which are valuable active pharmaceutical ingredients for the treatment of disorders of the cardiovascular system, in particular for the treatment of arrhythmias, for the prevention of sudden cardiac death or for influencing a reduced contractility of the heart. The invention further relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical preparations containing them. |