| abstract |
The invention relates to rationally designed peptides, their production and their use for biotechnical, medical technology, diagnostic and therapeutic purposes. DOLLAR A The method for generating peptides which are suitable for binding autoantibodies is characterized by DOLLAR A - identification of a seed peptide with the appropriate activity, DOLLAR A - generation of a small selection of peptide variants from the physicochemical space around the seed peptide with the aid a computer-aided calculation method, DOLLAR A - synthesis and testing of the activity of these peptide variants, DOLLAR A - modeling of a quantitative sequence / activity relationship by means of an artificial neural network and DOLLAR A - generation of peptides by simulated evolution in the sequence space by means of the trained neural network. DOLLAR A In particular, it is the peptide DRFGDKDIAF. |