http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-19821831-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d5fe74855697fef20a2e98a9b005db19 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-565 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-565 |
| filingDate | 1998-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2381106289b1eb043ff2c7b3ea9fbba8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d6ac784dbb1fa9c0eff163639e614869 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ff9e5054e353fad461ad22a00fc5861 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_37150e89bdb8f73ca517bc297d52bc71 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3716c8a09a8e43f851c19822609ed0c2 |
| publicationDate | 1999-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-19821831-A1 |
| titleOfInvention | Pharmaceutical preparations for the targeted substitution of estrogen deficiency in the central nervous system |
| abstract | The present invention relates to the use of selected steroids for the production of pharmaceutical preparations for the targeted substitution of estrogen deficiency in the central nervous system (CNS) without influencing other organs or systems. DOLLAR A These steroids are characterized by the fact that, in contrast to systemically effective natural and synthetic estrogens, including 17alpha-estradiol, they have selective neurotropic, estrogen-like transcription effects. DOLLAR A It was surprisingly found that the selected steroids in their use according to the invention DOLLAR A - cause a selective influence on the transcription of estrogen-dependent genes in the CNS and changes in corresponding physiological parameters; DOLLAR A - CNS specific transcription effects in doses that have no biological effects in tissues of the reproductive system; DOLLAR A - CNS-specific transcription effects at such doses in which neither 17beta-estradiol nor 17alpha-estradiol show efficacy; DOLLAR A - and the transcription of estrogen-dependent genes in the CNS do not influence the effect of secondary 17beta-estradiol. |
| priorityDate | 1998-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 438.